Job Description

Cincinnati Children's is:

• Recognized by U.S. News & World Report as a top 10 best children's hospitals in the nation for more than 15 years
• Second Among All Children's Hospitals for National Institutes of Health (NIH) Funding
• Recognized as one of America’s Best Large Employers (2025) , America’s Best Employers for New Grads (2024)
• One of the nation's America’s Most Innovative Companies as noted by Fortune
• Consistently certified as great place to work
• A Leading Disability Employer as noted by the National Organization on Disability
• Magnet® designated for the fourth consecutive time by the American Nurses Credentialing Center (ANCC)

A Leader in Lung Development and Disease Research

Researchers in our Division of Pulmonary Biology—one of the largest programs of its kind in the U.S.—have profoundly impacted modern lung biology, pulmonary medicine and neonatal care.

Researching the Developmental Processes that Build the Lung

We are interested in the normal developmental processes that build the lung and how such processes go awry during lung malformations, injury and tumorigenesis. We particularly focus on intercellular signaling and transcriptional control, using a combination of mouse genetics, single-cell genomics and 3D imaging.

Lab Projects

Holistic view of lung biology with cellular precision

As genome sequencing has cataloged DNA blueprints and cell atlas endeavor is cataloging constituent cell populations of each organ, our view of lung biology is increasingly genome-wide with a single-cell precision.

Signaling roles of AT1 cells toward the vasculature and mesenchyme

Alveolar type 1 (AT1) cells, an ultrathin expansive epithelial cell type, cover 95% of the gas exchange surface. Recognizing their omnipresence, we have proposed and provided evidence that AT1 cells are not simply a structural component, but also have signaling roles toward surrounding vasculature and mesenchyme.

Transcriptional and epigenetic mechanisms of cell fate specification and activation

Combinatorial action of transcription factors and cell-type-specific deployment of epigenetic marks mold hundreds of cell types out of the same DNA blueprint.

Never a dull cell – tools to study subcellular structures and apoptosis

Molecular mechanisms must be executed by cells whose toolbox includes proliferation, apoptosis, as well as subcellular structures such as cytoskeleton, junctions, adhesions, organelles, etc. How molecular events are converted into cellular changes driving tissue morphogenesis and homeostasis is poorly understood, especially in the lung made of cells with elaborate processes in 3D.

Nature’s mutations – species-unique morphogenesis and cell fates

Mouse and human genetics has been instrumental to causally link gene mutations to disruptions in function. Evolution, in contrast, has engineered mutations to unlock species-unique morphology and physiology, representing an alternative, powerful path to identify gene function.

Somatic functional genomics – harnessing the power of CRISPR and single-cell genomics

Classical mouse genetics engineer's germline mutations that can be spatiotemporally activated in cell types and organs of interest.

JOB RESPONSIBILITIES

• Research, Teaching and/or Training: - Conduct research both independently and collaboratively that is often dependent upon or associated with other ongoing research projects or is service related. Ensure that all research functions operate at the highest level of quality, while maintaining fiscal soundness. May contributes toward a major research or teaching training program(s). Participate in mentoring graduate students, post-doctoral and research fellows, residents, and students to be involved in functions related to the research mission. Demonstrate advancing contributions to research and teaching including: recognition as a teacher, role model and mentor internally; may lead research, teaching, training program; outside recognition of research or teaching as demonstrated by local and/or regional; contributes toward the development and direction of research and/or educational program at the division, department or system level. Recognized within the department as a role model in mentoring students and trainees. Complete evaluations for students, residents and peers. Maintain currency in field through continuing education, literature and seminars. Enhance professional knowledge by attending seminars and professional meetings. Implement knowledge into research.

• Service and/or Administration: - Participates in program development for service and/or administration as evidenced by one of the following: make contributes to the development of a research or educational programs or take a role in the direction of a research area or division; or provide consultation on a specific program development; or participates in performance improvement programs or on divisional, departmental, or research committees (i.e., IRB); participates in local or regional research/scientific affairs through membership in societies or specialty governing boards. May take a role in the development of departmental policies, procedures and standards. Promote interpersonal and intrapersonal relationships and encourage team concepts. Assist in the development and implementation of long and short term goals and objectives and ensures that they are appropriate to the Division. Complete evaluations for students, residents and peers. Coordinate, evaluate and manage annual fiscal operating and equipment budgets. Conduct fiscal analysis and monitor fiscal utilization of scope of services.

• Scholarly Activity: - Participates in scholarly activities. Responsible for initiating, soliciting, and coordinating new well-designed research projects that have potential for external funding. Present experimental results at scientific meetings. Applies advanced training in research methods to design and conduct clinical research on various areas of clinical specialty. Collaborate and write major grant proposals that will result in substantial extramural support. Seek and receive sustained and substantial support from local, regional and/or national sources such as the NIH and NSF either as principal investigator or as a co-investigator. Participate in collaborative research projects through interactions with researchers as well as individuals from other divisions/departments. Publish results of your research via independent and collaborative writings. Propose research and manage the development, implementation and assessment of long and short term goals and objectives. Maintain Quality Control programs; ensure that Quality Control Checks are conducted and records are maintained on each procedure. Define and review performance criteria for quality control, proficiency testing and reporting of test results. Assure that corrective action is taken and documented on all unaccepted control and proficiency testing results.

JOB QUALIFICATIONS

• PhD degree in a related scientific or research field

• 5+ years related experience in research field research and/or Lab experience AND assisting with the preparation of data for presentation at scientific meetings

• Associate Professor appointment or eligibility required

*Benefits may vary based on FTE Status and Position Type

Primary Location

Location R

Schedule

Full time

Shift

Day (United States of America)

Department

Pulmonary Biology Division Dir

Employee Status

Regular

FTE

1

Weekly Hours

40

Comprehensive job description provided upon request.

Cincinnati Children’s is proud to be an Equal Opportunity Employer committed to creating an environment of dignity and respect for all our employees, patients, and families. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, age, genetic information, national origin, sexual orientation, gender identity, disability or protected veteran status. EEO/Veteran/Disability